Related Experiment Video

Updated: Apr 30, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.8K

Importance of vascular calcification in kidney transplant recipients

Giuseppe Cianciolo1, Irene Capelli, Maria Laura Angelini

  • 1Nephrology, Dialysis and Transplantation Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola University Hospital, Bologna, Italy.

American Journal of Nephrology
|May 14, 2014
PubMed

Insights

Vascular calcification (VC) significantly predicts cardiovascular events and mortality in kidney transplant recipients (KTRs). Assessing VC using coronary artery calcification (CAC) and aorta calcification (AoC) scores is crucial for KTRs.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiovascular events are the leading cause of death in kidney transplant recipients (KTRs).
  • Vascular calcification (VC) significantly impacts morbidity and mortality in KTRs, yet its role is often underestimated.
  • Chronic kidney disease (CKD) patients face high cardiovascular risks, with transplantation being the primary treatment.

Purpose of the Study:

  • To review studies on vascular calcification (VC) in KTRs.
  • To compare VC findings in KTRs with CKD and dialysis populations.
  • To evaluate VC assessment methods and risk factors for progression.

Main Methods:

  • Review of 13 studies on VC in KTRs.
  • Focus on coronary artery calcification (CAC) and aorta calcification (AoC) scoring.
  • Analysis of traditional and non-traditional risk factors influencing VC progression.

Main Results:

  • VC strongly predicts cardiovascular events and mortality in KTRs.
  • CAC progression slows post-transplant but continues.
  • Low 25(OH)D3 levels and diabetes are associated with CAC progression, while improved secondary hyperparathyroidism is protective.

Conclusions:

  • VC assessment using CAC and AoC scores is vital for KTRs.
  • Quantitative measurement of calcium burden is essential before and after kidney transplant.
  • Risk factor management is key to mitigating VC progression and cardiovascular events in KTRs.
Abstract

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K
Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

16.6K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
631
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
926
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
740
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.3K