Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positive Regulator Molecules02:39

Positive Regulator Molecules

5.3K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.3K
Positive Regulator Molecules01:45

Positive Regulator Molecules

100.8K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
100.8K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

4.3K
4.3K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.3K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same author

Neoadjuvant immune checkpoint inhibitors for localized dMMR/MSI-H gastric cancer: a meta-analysis.

ESMO open·2026
Same author

Survey investigating the use of pain scales in dogs and cats in Australia.

The Journal of small animal practice·2025
Same author

Morphology and molecular evidence of a new species of Characidium (Characiformes: Crenuchidae) from the edges of a protected area at Rio Itararé, upper Rio Paraná, southern Brazil.

Journal of fish biology·2024
Same author

One-step laparoscopy-guided abomasopexy versus omentopexy via right flank laparotomy to treat left displaced abomasum in dairy cows, in relation to return of milk yield.

Veterinary journal (London, England : 1997)·2023
Same author

The use of pain scales in small animal veterinary practices in the USA.

The Journal of small animal practice·2022
Same journal

Spatiotemporal heterogeneity of gestational syphilis in the 1st Health Region of Pará in the Brazilian Amazon.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Pulmonary infection by non-tuberculous mycobacteria in an endemic region for tuberculosis in Northeast Brazil.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Zingerone alleviates diabetic nephropathy by interrupting the ER stress-inflammation-apoptosis cascade in streptozotocin-induced diabetic mice.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Helicobacter pylori outer membrane vesicle-induced hsa-miR-302a-3p and hsa-miR-184 promote the occurrence and development of gastric cancer.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

10.3K

Cyclin D1 expression in prostate carcinoma.

R A Pereira1, R C Ravinal1, R S Costa1

  • 1Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|May 14, 2014
PubMed
Summary
This summary is machine-generated.

High cyclin D1 expression in prostate cancer is linked to aggressive tumors. This finding suggests cyclin D1 may serve as a biomarker for prostate carcinoma aggressiveness.

More Related Videos

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

7.9K
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

12.7K

Related Experiment Videos

Last Updated: Apr 30, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

10.3K
A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

7.9K
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

12.7K

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Prostate carcinoma is a significant health concern.
  • Understanding molecular markers for tumor aggressiveness is crucial for patient management.

Purpose of the Study:

  • To investigate the correlation between cyclin D1 expression and clinicopathological parameters in prostate carcinoma patients.

Main Methods:

  • Immunohistochemistry was used to assess cyclin D1 expression in 85 prostate carcinoma samples and 10 normal prostate tissues.
  • Nuclear immunostaining was quantified as the percentage of positive tumor cells.
  • Correlation with clinicopathological parameters including Gleason score and prostate-specific antigen (PSA) levels was analyzed.

Main Results:

  • Cyclin D1 expression was detected in 75.4% of prostate carcinoma cases and was absent in normal prostate tissues.
  • High-grade Gleason score (≥7) was significantly associated with higher cyclin D1 expression (P<0.05).
  • Perineural invasion showed a trend towards association with cyclin D1 expression (P=0.07).

Conclusions:

  • Elevated cyclin D1 expression is associated with aggressive features in prostate carcinoma.
  • Cyclin D1 may represent a potential biomarker for predicting tumor aggressiveness in prostate cancer.