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Updated: Apr 29, 2026

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
Published on: May 4, 2018
Mitral valve endocarditis caused by Pseudomonas aeruginosa: a case report
Marija Polovina1, Tatjana Potpara, Ivana Milošević
1Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia. maki.marijapolovina@gmail.com.
Abstract:
Previously, endocarditis caused by Pseudomonas aeruginosa mostly involved right-sided valvular infection and generally carried a good prognosis. Recently, changes have been observed in the occurrence and clinical presentation of pseudomonal endocarditis, with increasing incidence of nosocomial infections and involvement of the aortic and mitral valves. Still, pseudomonal left-sided endocarditis is rare, but is frequently associated with complications and high mortality rates. A case of a high-risk patient with coronary artery disease and left-ventricular dysfunction, successfully treated for pseudomonal mitral valve endocarditis complicated by splenic abscess formation, is presented here.
Insights
Pseudomonas aeruginosa endocarditis is shifting towards left-sided infections, posing higher risks. This case highlights successful treatment of a complex mitral valve infection in a high-risk patient.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Microbiology
Background:
- Pseudomonas aeruginosa (PA) endocarditis traditionally affects the right side of the heart with a favorable prognosis.
- Recent trends indicate a rise in nosocomial PA endocarditis, with increased involvement of left-sided valves (aortic and mitral).
- Left-sided PA endocarditis is uncommon but associated with severe complications and elevated mortality.
Observation:
- A high-risk patient with coronary artery disease and left-ventricular dysfunction presented with mitral valve endocarditis.
- The infection was caused by Pseudomonas aeruginosa.
- Complications included splenic abscess formation.
Findings:
- Successful treatment of Pseudomonas aeruginosa mitral valve endocarditis was achieved in a complex patient.
- The treatment strategy effectively managed both the valvular infection and the splenic abscess.
Implications:
- This case underscores the evolving clinical landscape of PA endocarditis, emphasizing the need for vigilance in left-sided infections.
- Successful management in high-risk individuals suggests that aggressive treatment strategies can overcome significant complications.
- Further research into optimal therapeutic approaches for complex left-sided PA endocarditis is warranted.
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