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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

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Hemophagocytic lymphohistiocytosis and dengue infection: rare case report

A-S De Koninck, J Dierick, S Steyaert

    Acta Clinica Belgica
    |May 14, 2014
    PubMed

    We describe a 21-year-old female patient returning from a journey to Cambodia, who developed dengue fever complicated with hemophagocytic lymphohistiocytosis. Hectic fever, rash, leukopenia, thrombocytopenia, hepatocellular dysfunction, a markedly elevated ferritin level, and a bone marrow demonstrating abundant hemophagocytosis were present. The patient recovered within 14 days. To our knowledge, this is only the second reported case of dengue virus-associated hemophagocytosis in Europe. As dengue is a rising pathogen in tropical import diseases, clinicians must be aware of its rare but serious complications.

    Keywords:
    Hemophagocytic lymphohistiocytosis,Hemophagocytic syndromeInfection-associated hemophagocytic syndrome,Pancytopenia,Primary dengue infection,

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