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Updated: Apr 29, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane
Wiroon Sangsiraprapha, Luan Truong, Sreedhar Mandayam1
1Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Abstract:
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides is an important cause of rapidly progressive glomerulonephritides (RPGN), and they are classically described as pauci-immune diseases as evidenced by the absence of immune deposits on immunofluoresence microscopy of the kidney biopsy. We report two patients with RPGN, pulmonary-renal syndrome, positive ANCA serology and linear Immunoglobulin G (IgG) staining on glomerular basement membrane in the absence of detectable anti-glomerular basement membrane (anti-GBM) antibodies in the serum.
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