Reference absolute and indexed values for left and right ventricular volume, function and mass from cardiac computed...

Area of Science:

• Cardiovascular Imaging
• Radiology
• Cardiac CT Analysis

Background:

• Left ventricular (LV) and right ventricular (RV) parameters are crucial biomarkers for heart failure prognosis.
• Accurate volumetric and functional assessment is vital for patient management.

Purpose of the Study:

• To establish reference mean values for LV and RV volume, function, and mass.
• Normalization by age, gender, and body surface area (BSA) using 64-slice cardiac computed tomography (CCT).
• Utilize automated analysis software for retrospective electrocardiographically gated CCT data.

Main Methods:

• Retrospective analysis of CCT data from 74 healthy adults.
• Automated software used for LV/RV volume, LV mass, and ejection fraction analysis.
• Statistical analysis (general linear model, Bland-Altman) adjusted for age, gender, and BSA.

Main Results:

• Established age, gender, and BSA-normalized reference ranges for LV/RV parameters.
• Significant gender-based differences observed in LV mass and RV volume (P < 0.0001).
• Age and gender influenced RV end-diastolic volume and LV ejection fraction (P < 0.05).

Conclusions:

• CCT datasets can reliably report normalized LV and RV parameters.
• These findings provide valuable data for heart failure patient management.
• Automated analysis offers reproducible results with acceptable agreement.