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Development of Antibiotic Resistance01:30

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Who will develop new antibacterial agents?

Stewart T Cole1

  • 1Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, , Station 19, 1015 Lausanne, Switzerland.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 14, 2014
PubMed
Summary
This summary is machine-generated.

The antimicrobial drug development pipeline is nearly empty due to an unsustainable pharmaceutical business model and funding gaps. Concerted international efforts are urgently needed to combat rising multidrug-resistant bacteria.

Keywords:
antibioticsbiotechnologydrug discoverydrug resistancepharmaceutical industry

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Drug Development

Background:

  • The era of novel antimicrobial drug discovery has waned, with a significant decline in new drug development.
  • The pharmaceutical industry's shift away from anti-infectives has led to a critically depleted drug development pipeline.
  • Public sector funding for drug discovery generates leads that are often stalled due to funding deficits, particularly for clinical trials.

Purpose of the Study:

  • To analyze the factors contributing to the current crisis in antimicrobial drug development.
  • To explore potential solutions for revitalizing the antimicrobial pipeline.
  • To highlight the urgent need for international collaboration in developing new antimicrobials.

Main Methods:

  • Retrospective analysis of historical trends in antimicrobial drug development.
  • Examination of the economic and funding models within the pharmaceutical industry and public sector.
  • Review of the challenges in antimicrobial drug efficacy testing, including clinical trials.

Main Results:

  • The current business model for antimicrobial development is unsustainable, leading to industry abandonment of the sector.
  • Publicly funded research often fails to translate into pursued drug development due to funding gaps, especially for costly clinical trials.
  • A lack of coordinated global strategy exacerbates the threat of multidrug-resistant bacteria.

Conclusions:

  • Urgent and concerted international action is required to address the antimicrobial resistance crisis.
  • Innovative funding mechanisms and business models are necessary to incentivize antimicrobial drug development.
  • Overcoming funding gaps, particularly for clinical trials, is crucial for replenishing the antimicrobial pipeline.