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The association between airflow obstruction and radiologic change by tuberculosis
Yong Il Hwang1, Joo Hee Kim1, Chang Youl Lee1
1Division of Pulmonology, Allergy & Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Seoul, Republic of Korea.
Journal of Thoracic Disease
|May 14, 2014
Summary
Tuberculosis (TB) lung damage is linked to airflow obstruction, a key feature of chronic obstructive pulmonary disease (COPD). This finding highlights TB as a significant risk factor for COPD in adults over 40.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Radiology
Background:
- Cigarette smoking is the primary risk factor for chronic obstructive pulmonary disease (COPD).
- Non-smokers can develop chronic airflow limitation, indicating other risk factors exist.
- Previous studies suggest a link between a history of tuberculosis (TB) and airflow obstruction in adults over 40.
Purpose of the Study:
- To investigate the association between radiologic evidence of tuberculosis and airflow obstruction.
- To evaluate TB as a potential risk factor for COPD in a population-based sample.
Main Methods:
- A nationwide COPD prevalence survey was conducted in Korea.
- 1,384 adults over 40 years old underwent spirometry and chest radiography.
- Airflow obstruction was defined as a FEV1/FVC ratio less than 0.7.
Main Results:
- 10.8% of subjects had airflow obstruction, and 12.1% showed radiologic changes consistent with TB.
- Subjects with radiologic TB changes had a significantly higher prevalence of airflow obstruction (26.3%) compared to those without (8.6%).
- The unadjusted odds ratio for airflow obstruction in subjects with radiologic TB changes was 3.788 (95% CI: 2.544-5.642).
Conclusions:
- Radiologic evidence of tuberculosis is significantly associated with airflow obstruction.
- Tuberculosis may be an important risk factor for developing COPD, particularly in adults over 40.
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