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Hemoglobin in normal range, the lower the better?-Evidence from a study from Chinese community-dwelling participants

Lianxiang Ren1, Bing Gu1, Yixing Du1

  • 11 Department of Medical Examination Center, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China ; 2 Department of Laboratory Medicine, 3 Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Clinical Laboratory Medicine, BenQ Medical Center, Nanjing 210019, China ; 5 Department of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China ; 6 Department of Gerontology, 7 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 8 Department of Laboratory Medicine, Jiangsu Shengze Hospital, Wujiang 215228, China.

Journal of Thoracic Disease
|May 14, 2014
PubMed

Insights

Higher hemoglobin (Hb) levels, even within the normal range, are linked to increased cardiovascular risk factors like obesity and high blood pressure. A slightly lower Hb level may be beneficial for Chinese adults.

Area of Science:

  • Cardiovascular Health
  • Hematology
  • Public Health

Background:

  • Hemoglobin (Hb) levels play a crucial role in oxygen transport.
  • Understanding the association between Hb and cardiovascular risk factors is vital for preventative strategies.

Purpose of the Study:

  • To investigate the relationship between hemoglobin levels and cardiovascular risk factors in a large community-dwelling cohort.
  • To determine if elevated Hb levels, even within the normal range, are associated with increased cardiovascular risk.

Main Methods:

  • A cohort study involving 4,186 women and 4,851 men.
  • Data collection included personal history, physical examination, and biochemical parameters.
  • Pearson's correlation and binary logistic regression analyses were used to examine associations.

Main Results:

  • Hemoglobin levels showed a positive association with body mass index (BMI), total cholesterol (TC), triglycerides (TG), uric acid (UA), diastolic blood pressure (DBP), and fasting plasma glucose (FPG) in both genders.
  • Increased Hb levels correlated with a higher incidence of hyperuricemia and obesity.
  • Hb level was identified as a significant risk factor for elevated blood pressure.

Conclusions:

  • Elevated hemoglobin levels, even within the normal range, are associated with a higher prevalence of cardiovascular risk factors.
  • A slightly lower hemoglobin level may be beneficial for cardiovascular health in Chinese community-dwelling individuals.
Abstract

Keywords:
Hemoglobinblood pressurecardiovascular risk

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