Donor cell myeloid sarcoma

Area of Science:

• Hematology
• Oncology
• Transplantation

Background:

• Allogeneic bone marrow transplantation (BMT) can lead to rare complications.
• Donor cell-derived malignancies represent a unique post-transplant event.
• Myeloid sarcoma is an extramedullary tumor of myeloid blasts.

Purpose of the Study:

• To report a rare case of donor cell-derived myeloid sarcoma.
• To describe the occurrence of this malignancy in the stomach and myocardium.
• To add to the literature on complications following allogeneic BMT.

Main Methods:

• Case presentation of a 56-year-old male recipient.
• Review of clinical course and diagnostic findings.
• Histopathological confirmation of donor origin.

Main Results:

• The patient developed myeloid sarcoma originating from donor cells.
• The malignancy manifested in unusual sites: stomach and myocardium.
• This represents a rare instance of extramedullary disease post-BMT.

Conclusions:

• Donor cell-derived myeloid sarcoma is a rare but significant complication.
• The stomach and myocardium are potential sites for this malignancy.
• Awareness is crucial for timely diagnosis and management in BMT recipients.