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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Updated: Apr 29, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Donor cell myeloid sarcoma.

Mark A Walshauser1, Aileen Go2, Payal Sojitra3

  • 1Division of Hematology & Oncology, Department of Internal Medicine, Loyola University Medical Center, Maywood, IL 60153, USA ; Division of Hematology & Oncology, Department of Medicine, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Maywood, IL 60153, USA.

Case Reports in Hematology
|May 14, 2014
PubMed
Summary
This summary is machine-generated.

Donor cell malignancies are a rare complication of allogeneic bone marrow transplantation. This case highlights donor cell myeloid sarcoma affecting the stomach and heart in a transplant recipient.

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Area of Science:

  • Hematology
  • Oncology
  • Transplantation

Background:

  • Allogeneic bone marrow transplantation (BMT) can lead to rare complications.
  • Donor cell-derived malignancies represent a unique post-transplant event.
  • Myeloid sarcoma is an extramedullary tumor of myeloid blasts.

Purpose of the Study:

  • To report a rare case of donor cell-derived myeloid sarcoma.
  • To describe the occurrence of this malignancy in the stomach and myocardium.
  • To add to the literature on complications following allogeneic BMT.

Main Methods:

  • Case presentation of a 56-year-old male recipient.
  • Review of clinical course and diagnostic findings.
  • Histopathological confirmation of donor origin.

Main Results:

  • The patient developed myeloid sarcoma originating from donor cells.
  • The malignancy manifested in unusual sites: stomach and myocardium.
  • This represents a rare instance of extramedullary disease post-BMT.

Conclusions:

  • Donor cell-derived myeloid sarcoma is a rare but significant complication.
  • The stomach and myocardium are potential sites for this malignancy.
  • Awareness is crucial for timely diagnosis and management in BMT recipients.