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Cancer wars: natural products strike back
Christine Basmadjian1, Qian Zhao1, Embarek Bentouhami2
1Therapeutic Innovation Laboratory, UMR7200, CNRS/University of Strasbourg Illkirch, France ; AAREC Filia Research Clichy, France.
Frontiers in Chemistry
|May 14, 2014
Summary
Natural products are regaining importance in cancer drug discovery, with 12 new derivatives approved since 2007. This review covers their development and future trends in natural product anticancer therapies.
Area of Science:
- Pharmacology
- Medicinal Chemistry
- Oncology
Background:
- Natural products were historically crucial for anticancer drug development.
- The rise of targeted therapies led to a decline in natural product research.
- Limited success of targeted therapies in solid tumors has renewed interest in natural products.
Purpose of the Study:
- To review the discovery and development of novel anticancer drugs derived from natural products.
- To highlight the unique characteristics of natural product drug discovery.
- To discuss emerging trends in the field.
Main Methods:
- Literature review of natural product-derived anticancer drugs.
- Analysis of drug approval data.
- Discussion of scientific literature on natural product research and development.
Main Results:
- Twelve novel natural product derivatives have been approved since 2007, including rapamycin.
- Natural products offer a valuable source for anticancer drug discovery, especially for solid tumors.
- Significant advancements and new trends are emerging in this field.
Conclusions:
- Natural products represent a vital and revitalized source for novel anticancer drug discovery.
- Continued research into natural products is essential for addressing unmet needs in cancer treatment.
- The field is dynamic, with promising new trends shaping future drug development.
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