Studies toward spasticity suppression with high frequency electrical stimulation

A technique employing high frequency stimulation of the muscle nerve is investigated as a potential treatment procedure for temporary and longterm suppression of spasticity. Animal experiments show that reversible inhibition of up to 95% of the maximal muscle force is possible with optimal stimulation frequency of 600 pulses per second. The data indicate that the possible blockade of neuromuscular activity is due to interruption of action potential transmission across the end plates or inhibition of binding sites due to Ca+ depletion.