Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.9K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

14.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.6K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Periosteal chondrosarcoma: a case report and review of the literature.

Archives of pathology & laboratory medicine·1997
Same author

Femoral lengthening by callus distraction and cortical apposition (Z-osteotomy).

Clinical orthopaedics and related research·1994
Same author

Pyogenic sacroiliitis in children.

Clinical orthopaedics and related research·1993
Same author

Foreign-body osteitis of the metacarpal bone.

Clinical orthopaedics and related research·1992
Same author

Cartilage necrosis due to pin penetration: experimental studies in rabbits.

Journal of pediatric orthopedics·1991
Same author

Interspinous Drummond wire instrumentation in traumatic cervical spine instability.

Spine·1991

Related Experiment Video

Updated: Apr 29, 2026

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
06:40

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

8.2K

Benign chondroblastoma.

H Aprin

    Orthopedics
    |May 15, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Benign chondroblastoma treatment involving curettage and bone grafting showed good healing in most patients. Early motion and protected weight-bearing are crucial for managing complications and ensuring recovery.

    More Related Videos

    Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
    08:58

    Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

    Published on: May 21, 2013

    13.9K
    Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
    07:23

    Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

    Published on: December 3, 2016

    13.2K

    Related Experiment Videos

    Last Updated: Apr 29, 2026

    Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
    06:40

    Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

    Published on: October 21, 2015

    8.2K
    Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
    08:58

    Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

    Published on: May 21, 2013

    13.9K
    Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
    07:23

    Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

    Published on: December 3, 2016

    13.2K

    Area of Science:

    • Orthopedic Surgery
    • Bone Tumors
    • Musculoskeletal Oncology

    Background:

    • Benign chondroblastoma is a rare bone tumor typically affecting adolescents and young adults.
    • Common symptoms include pain and limited joint motion, particularly in the epiphyses of long bones.
    • Diagnosis relies on a combination of radiographic, pathological, and microscopic evaluations.

    Discussion:

    • Curettage and bone grafting is a standard surgical approach for benign chondroblastoma.
    • Post-operative management is critical to prevent complications such as joint stiffness and subchondral fractures.
    • Long-term follow-up is necessary to monitor for potential recurrence.

    Key Insights:

    • Four out of six patients achieved complete healing within three years after curettage and bone grafting.
    • One case of recurrence in the femoral head highlights the importance of vigilant monitoring.
    • Early range-of-motion exercises and progressive protected weight-bearing significantly reduce post-surgical complications.

    Outlook:

    • Further research could explore minimally invasive techniques for chondroblastoma treatment.
    • Investigating factors influencing recurrence rates may refine long-term management strategies.
    • Optimizing rehabilitation protocols can enhance functional outcomes and patient recovery.