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Methicillin-resistant Staphylococcus aureus colonization and disease severity in atopic dermatitis: a cross-sectional

Soumya Jagadeesan, George Kurien1, Manjula Velikkakathu Divakaran

  • 1Department of Dermatology and Venereology, Government Medical College, Kottayam, Kerala, India.

Indian Journal of Dermatology, Venereology and Leprology
|May 15, 2014
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) colonization is common in children with atopic dermatitis, affecting over 25%. MRSA colonization is linked to more severe eczema, indicating a potential role in disease severity.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pediatrics

Background:

  • Colonization by methicillin-resistant Staphylococcus aureus (MRSA) in atopic dermatitis (AD) is understudied.
  • MRSA may contribute to AD severity due to its virulence factors.

Purpose of the Study:

  • To determine the prevalence of MRSA colonization in pediatric AD patients.
  • To investigate the association between MRSA colonization and AD severity.

Main Methods:

  • An observational, cross-sectional study of children (≤12 years) with AD.
  • Collected socio-demographic data, risk factors for healthcare-associated MRSA, and Eczema Area Severity Index (EASI) scores.
  • Obtained skin swabs from nares and affected skin sites for microbial culture.

Main Results:

  • Staphylococcus aureus isolated from 92.4% of 119 subjects; MRSA detected in 25.21%.
  • MRSA colonization was significantly associated with higher EASI scores (P < 0.01).
  • 18 MRSA patients had risk factors for healthcare-associated MRSA.

Conclusions:

  • High prevalence of MRSA (25.2%) in pediatric atopic dermatitis.
  • MRSA colonization is associated with increased atopic dermatitis severity.
  • Further research is required to confirm these findings.

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