Related Experiment Video

Updated: Apr 29, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

6.5K

Birth outcomes of cases with conotruncal defects of heart - a population-based case-control study

Attila Vereczkey1, Zsolt Kósa, Melinda Csáky-Szunyogh

  • 1Versys Clinics, Human Reproduction Institute , Budapest , Hungary .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 15, 2014
PubMed

Insights

Conotruncal defects (CTDs) are linked to lower birth weight and intrauterine growth restriction, especially in female infants. Common truncus is an exception, affecting gestational age and birth weight differently.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Neonatology

Background:

  • Congenital heart defects are a significant concern in newborns.
  • Conotruncal defects (CTDs) represent a group of severe congenital heart anomalies.
  • Understanding the impact of CTDs on birth outcomes is crucial for clinical management.

Purpose of the Study:

  • To evaluate and compare birth outcomes in infants with four specific conotruncal defects (CTDs).
  • The CTDs studied include common truncus, transposition of great arteries, tetralogy of Fallot, and double-outlet right ventricle.

Main Methods:

  • A population-based dataset from the Hungarian Case-Control Surveillance of Congenital Abnormalities was utilized.
  • Birth outcomes of 597 live-born cases with CTD were compared to 38,151 population controls.
  • Socio-demographic data of mothers were also incorporated into the analysis.

Main Results:

  • Infants with CTDs showed a male predominance (56.8%) but similar gestational age and preterm birth rates compared to controls.
  • A significantly higher rate of low birth weight (14.6% vs. 5.7%) and smaller mean birth weight (3077g vs. 3276g) were observed in CTD cases.
  • Intrauterine growth restriction was noted in transposition of great arteries, tetralogy of Fallot, and double-outlet right ventricle, particularly in females. Common truncus cases had shorter gestational age and lower birth weight.

Conclusions:

  • Most CTDs, excluding common truncus, do not significantly affect gestational age but are associated with a high risk of intrauterine fetal growth restriction.
  • This growth restriction is particularly pronounced in female infants diagnosed with these heart defects.
  • Common truncus presents a distinct pattern of altered birth outcomes compared to other CTDs studied.
Abstract

Keywords:
Common truncuscongenital heart defectsdouble-outlet right ventricleintrauterine growth restrictionmale excesstetralogy of Fallottransposition of great vessels

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.0K
Implantation of Total Artificial Heart in Congenital Heart Disease07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

28.4K

Related Concept Videos

Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
1.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557