Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Heart rate circadian rhythm in patients with traumatic brain injury: A retrospective analysis of a nationwide multicenter ICU database.

American heart journal plus : cardiology research and practice·2026

Same author

Semaglutide exerts neuroprotective effects by blocking the interleukin-17/NOD-like receptor family pyrin domain containing 3-mediated neuroinflammation pathway after traumatic brain injury.

Neural regeneration research·2026

Same author

Application of artificial intelligence in non-invasive cardiovascular imaging for coronary artery disease: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine·2025

Same author

Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide prospective cohort study.

Cardiovascular diabetology·2025

Same author

Balancing Anti-Inflammation and Neurorepair: The Role of Mineralocorticoid Receptor in Regulating Microglial Phenotype Switching After Traumatic Brain Injury.

CNS neuroscience & therapeutics·2025

Same author

Association of atherogenic index of plasma trajectory with the incidence of cardiovascular disease over a 12-year follow-up: findings from the ELSA cohort study.

Cardiovascular diabetology·2025

Same journal

Role of incretins in Alzheimer's disease and their impact on behavioral aspects.

Chinese medical journal·2026

Same journal

Asparagine-linked glycosyltransferase 6 deficiency suppresses tumorigenesis in clear cell renal cell carcinoma by regulating apoptosis and immunotherapy sensitivity.

Chinese medical journal·2026

Same journal

Impact of joint effect of parental anthropometrics on fetal growth trajectories: A national multicenter cohort study.

Chinese medical journal·2026

Same journal

Novel treatments for Parkinson's disease.

Chinese medical journal·2026

Same journal

Incidence, DALYs, and death rates of chronic kidney disease in China, 1990-2023: Results from the Global Burden of Disease Study 2023.

Chinese medical journal·2026

Same journal

Reclassifying renal cell carcinoma with pathologic lymph node metastasis: An approach to refining prognostic stratification in patients with AJCC III and IV stages.

Chinese medical journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 29, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Research progress in traumatic brain penumbra.

Kai Wang¹, Baiyun Liu², Jun Ma¹

¹Imaging Center of Neuroscience, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

Chinese Medical Journal

|May 15, 2014

Summary

This summary is machine-generated.

The traumatic penumbra, brain tissue surrounding traumatic brain injury (TBI) lesions, is crucial for recovery. Advanced imaging techniques offer better insights into its pathophysiology and potential for brain rescue.

More Related Videos

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

Related Experiment Videos

Last Updated: Apr 29, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

Area of Science:

Neuroscience
Pathology
Radiology

Background:

Traumatic brain injury (TBI) can lead to secondary injury in the surrounding brain tissue, known as the traumatic penumbra.
This penumbra region holds potential for recovery after the initial insult.

Purpose of the Study:

To review the existence and significance of the traumatic penumbra.
To analyze pathological changes and brain imaging in the context of TBI and the penumbra.

Main Methods:

Comprehensive literature search of Medline and ISI databases (1995-2013).
Inclusion of all relevant studies on TBI and traumatic penumbra, regardless of research design or language.
Exclusion of duplicated articles and synthesis of extracted information.

Main Results:

Key pathological changes post-TBI include altered cerebral blood flow, edema, blood-brain barrier damage, apoptosis, and necrosis.
Traditional imaging methods have limitations in early characterization of cerebral blood flow reduction and pathophysiology.
Advanced imaging techniques like diffusion tensor imaging (DTI) and positron emission tomography (PET) show promise in better characterizing TBI pathophysiology.

Conclusions:

The evolution of the traumatic penumbra is critical for the future of traumatic brain lesions.
Understanding the formation, pathophysiology, and imaging of the traumatic penumbra is vital for early clinical diagnosis and timely intervention.
Further research into advanced imaging techniques for the traumatic penumbra is essential for improved patient outcomes.