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Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: report of 2 cases
Henry K Su1, Beverly Y Wang, Abul Ala Syed Rifat Mannan
1Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York; Department of Otolaryngology - Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York.
Background:
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low-grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.
Methods:
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.
Results:
Two patients who were treated with wide local resection for HCCC and remained disease-free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.
Conclusion:
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long-term surveillance and potential intervention should nodal disease become manifest.
