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Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients

Chang-yi Wang1, Zhong-wei Chen2, Tao Zhang2

  • 1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, People's Republic of China.

European Journal of Internal Medicine
|May 15, 2014
PubMed

Insights

Elevated homocysteine levels increase ischemic stroke risk in hypertensive individuals, but not coronary heart disease. This study highlights homocysteine as a significant risk factor for stroke in this population.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Clinical Biochemistry

Background:

  • Hyperhomocysteinemia is linked to ischemic stroke (IS) and coronary heart disease (CHD) in the general population.
  • The association between homocysteine and cardiovascular events in hypertensive patients is not well-established.

Purpose of the Study:

  • To investigate the relationship between plasma total homocysteine (tHcy) levels and the presence of IS and CHD in Chinese hypertensive patients.

Main Methods:

  • A cross-sectional study of 5935 Chinese hypertensive patients in Shenzhen.
  • Plasma tHcy levels were measured using an enzyme cycle method.
  • IS and CHD diagnoses were confirmed through medical records and specialist adjudication.

Main Results:

  • Higher plasma tHcy levels were significantly associated with IS in both men and women.
  • Increased tHcy showed a dose-dependent association with IS risk (p-trend < 0.001).
  • No significant association was found between tHcy and the presence of CHD.

Conclusions:

  • Plasma homocysteine is positively associated with ischemic stroke in hypertensive Chinese patients.
  • Homocysteine does not appear to be significantly associated with coronary heart disease in this cohort.
Abstract

Keywords:
Coronary heart diseaseHomocysteineHypertensionIschemic stroke

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