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Thyroid cancer in hyperthyroid patients: is it different clinical entity?
Endocrine Regulations
|May 15, 2014
Summary
Thyroid cancer is frequently detected in patients undergoing surgery for hyperthyroidism. Pre-operative thyroid fine-needle aspiration biopsy (TFNAB) is recommended for diagnosing thyroid malignancy in these individuals.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Hyperthyroidism necessitates surgical intervention in some cases.
- The incidence of co-existing thyroid cancer in hyperthyroid patients requires investigation.
Purpose of the Study:
- To determine the frequency of thyroid cancer in patients who underwent thyroidectomy for hyperthyroidism.
- To assess the utility of pre-operative diagnostic methods for thyroid malignancy.
Main Methods:
- Retrospective analysis of 177 patients who underwent thyroidectomy for hyperthyroidism (August 2005 - March 2010).
- Collection and review of demographic, clinical, radiological, and laboratory data.
- Postoperative histopathological examination of surgical specimens.
Main Results:
- Thyroid malignancy was identified in 13 (7.3%) of the 177 patients.
- Among malignancies, multinodular toxic goiter (MTG) was most common (53.9%), followed by uninodular toxic goiter (UTG) (38.5%) and Graves' disease (7.6%).
Conclusions:
- Thyroid carcinoma is a significant finding in hyperthyroid patients undergoing thyroidectomy.
- Thyroid fine-needle aspiration biopsy (TFNAB) is a reliable diagnostic tool for thyroid malignancy in this population.
- Pre-surgical TFNAB evaluation of nodules in hyperthyroid patients is advisable.
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