Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

559
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

827
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

631
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
631

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial.

JAMA network open·2026
Same author

HIV-associated kidney diseases: progress, gaps, and future directions.

Clinical microbiology reviews·2025
Same author

Large language models in real-world clinical workflows: a systematic review of applications and implementation.

Frontiers in digital health·2025
Same author

A study of RNA splicing and protein expression in the living human brain.

PloS one·2025
Same author

Using Predictive Models and AI for AKI Research.

Seminars in nephrology·2025
Same author

Clinical applications and limitations of large language models in nephrology: a systematic review.

Clinical kidney journal·2025

Related Experiment Video

Updated: Apr 29, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

12.2K

HIV and the aging kidney.

Girish N Nadkarni1, Ioannis Konstantinidis, Christina M Wyatt

  • 1aDivision of Nephrology, Department of Medicine bDepartment of Medical Education, Icahn School of Medicine, New York, New York, USA *Girish N. Nadkarni and Ioannis Konstantinidis contributed equally to the writing of this article.

Current Opinion in HIV and AIDS
|May 15, 2014
PubMed
Summary
This summary is machine-generated.

Kidney disease is a growing concern for older adults with human immunodeficiency virus (HIV). HIV infection and aging increase kidney disease risk, requiring careful management due to polypharmacy and potential medication toxicity.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

18.6K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.2K

Related Experiment Videos

Last Updated: Apr 29, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

12.2K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

18.6K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.2K

Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Nephrology

Background:

  • Aging HIV-infected population presents unique health challenges.
  • Kidney disease is an increasingly significant comorbidity in older adults with HIV.
  • HIV infection and aging independently increase the risk of kidney disease.

Purpose of the Study:

  • To review unique considerations in the epidemiology, diagnosis, and management of kidney disease in older adults with HIV.
  • Highlight the interplay between HIV, aging, and kidney health.
  • Provide an overview of current challenges and future directions.

Main Methods:

  • Literature review of studies on HIV, aging, and kidney disease.
  • Analysis of epidemiological data and clinical management strategies.
  • Synthesis of recent findings on kidney function estimation and medication effects.

Main Results:

  • HIV may accelerate kidney disease progression, especially with co-existing traditional risk factors like diabetes.
  • Both HIV infection and older age elevate risks for acute and chronic kidney disease.
  • Newer creatinine-based kidney function estimates show promise but require further validation in older HIV-infected adults, with potential interference from certain HIV medications.

Conclusions:

  • Kidney disease is a critical factor in morbidity and mortality for the aging HIV-infected population.
  • While not necessarily causing premature aging of the kidneys, HIV and its treatments increase kidney disease risk.
  • Management requires careful consideration of polypharmacy and medication toxicity in this vulnerable group.