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Cardiovascular disease risk in an aging HIV population: not just a question of biology

Kaku So-Armah1, Matthew S Freiberg

  • 1aYale University School of Medicine, New Haven, Connecticut bUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Current Opinion in HIV and AIDS
|May 15, 2014
PubMed

Insights

Human immunodeficiency virus (HIV) and cardiovascular disease (CVD) risk are linked by multiple biological and environmental factors, especially in aging populations. These factors interact, increasing CVD risk in individuals with HIV.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a significant concern in the aging human immunodeficiency virus (HIV) population.
  • Understanding the interplay between HIV, biological factors, and environmental influences on CVD risk is crucial.

Purpose of the Study:

  • To review recent literature on the relationship between HIV, biological and environmental risk factors, and CVD risk.
  • To emphasize the impact on the aging HIV population.
  • To demonstrate the interactive effects of these factors on CVD risk in HIV-positive individuals.

Main Methods:

  • Literature review of recently published studies.
  • Analysis of biological mechanisms linking HIV and CVD.
  • Assessment of environmental factors contributing to CVD risk in HIV.

Main Results:

  • HIV-associated CVD risk is multifactorial, involving biological and environmental elements.
  • Key factors include HIV-related immunologic alterations, co-occurring multimorbidities, and polypharmacy.
  • Healthcare disparities in CVD risk reduction for HIV-positive individuals are also significant.

Conclusions:

  • Optimal treatment strategies are needed to balance immunological restoration with CVD risk reduction in HIV patients.
  • Further research is required to refine management approaches for this growing population.
Abstract

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