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HIV and aging: emerging research issues.

Peter W Hunt1

  • 1SFGH HIV/AIDS Division, University of California, San Francisco, California, USA.

Current Opinion in HIV and AIDS
|May 15, 2014
PubMed
Summary
This summary is machine-generated.

People with HIV face higher mortality and age-related diseases. Further research is needed to understand persistent inflammation and optimize care for an aging HIV population on antiretroviral therapy (ART).

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Gerontology

Background:

  • HIV-infected individuals experience increased mortality and age-related morbidities.
  • The modern antiretroviral therapy (ART) era has improved life expectancy but presents new challenges.
  • Persistent inflammation is a key factor in HIV-related morbidity and mortality.

Purpose of the Study:

  • To review current understanding of health challenges in aging HIV-infected individuals.
  • To address unresolved issues in the management of HIV in the ART era.
  • To guide future research priorities for improving long-term health outcomes in HIV.

Main Methods:

  • Comprehensive literature review of recent studies on HIV, aging, and inflammation.
  • Analysis of current data on life expectancy and morbidity in the ART era.
  • Identification of knowledge gaps and areas for future research.

Main Results:

  • Generalizability of current findings to an older HIV population remains uncertain.
  • The precise contributions of inflammation, behaviors, comorbidities, and ART toxicity to poor outcomes are not fully understood.
  • Root causes of persistent inflammation and optimal intervention targets/biomarkers require further investigation.

Conclusions:

  • Addressing persistent inflammation, understanding multifactorial morbidities, and identifying precise immunologic targets are crucial.
  • Future research should prioritize these areas to improve long-term health for people with HIV.
  • Recommendations are provided for prioritizing the future research agenda.