Migraine and inhibitory system - I can't hold it!
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Updated: Apr 29, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Caterina Mainero1, Celine Louapre
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129, USA, caterina@nmr.mgh.harvard.edu.
Abstract:
The exact pathophysiological mechanisms leading to the activation and sensitization of the trigeminovascular pathway, which in turns results in the migraine attack, are not completely elucidated. It is likely that direct activation by cortical spreading depression, together with dysfunctional central control of pain, plays a major role in the onset and spreading of the migraine attack. This review focuses on recent structural and functional neuroimaging studies that investigated the role of subcortical and cortical structures in modulating nociceptive input in migraine, which outlined the presence of an imbalance between inhibitory and excitatory modulation of pain processing in the disease.
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