Electrospun titania sol-gel-based ceramic composite nanofibers for online micro- solid-phase extraction with
Habib Bagheri1, Hamed Piri-Moghadam, Soroush Rastegar
1Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Journal of Separation Science
|May 15, 2014
Summary
New ceramic composite nanofibers were developed using titania and various transition metals. These materials show promise for efficiently extracting pharmaceuticals like naproxen and clobetasol from biological samples.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Sol-gel processing and electrospinning are advanced techniques for creating novel nanomaterials.
- Titania (TiO2) nanofibers offer unique properties for various applications.
- Incorporating transition metals can enhance material functionality.
Purpose of the Study:
- To synthesize novel ceramic composite nanofibers using titania and transition metals via electrospinning.
- To evaluate the efficacy of these nanofibers in micro-solid-phase extraction (µ-SPE).
- To determine the suitability of these materials for analyzing pharmaceutical compounds in biological matrices.
Main Methods:
- Titanium(IV) tetraisopropoxide and poly(vinylpyrrolidone) were used as precursors for sol-gel electrospinning.
- Four types of titania-based composite nanofibers were fabricated, incorporating Fe-Mn, Fe-Ni, Fe-Co, and Fe-Mn-Co-Ni.
- Scanning electron microscopy (SEM) was employed to characterize the morphology and diameter of the nanofibers.
- A micro-solid-phase extraction (µ-SPE) setup coupled with high-performance liquid chromatography (HPLC) was utilized for analyte determination.
Main Results:
- Homogeneous ceramic composite nanofibers with diameters ranging from 100-250 nm were successfully prepared.
- All fabricated composite nanofibers demonstrated comparable sorption efficiencies for naproxen and clobetasol.
- The specific type of transition metal incorporated had an insignificant effect on the sorption performance.
- The developed µ-SPE-HPLC method showed good linearity (1-1000 μg/L) and low limits of detection (0.3-2 μg/L).
Conclusions:
- The developed titania-based ceramic composite nanofibers are effective for the µ-SPE of pharmaceuticals.
- The method is suitable for analyzing naproxen and clobetasol in complex biological samples like urine and blood plasma.
- The transition metal composition has a minimal impact on the extraction efficiency of these analytes.
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