Related Experiment Video
Updated: Apr 29, 2026
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
Topical praziquantel as a new treatment for perioral dermatitis: results of a randomized vehicle-controlled pilot
M R Bribeche1, V P Fedotov, A Jillella
1Department of Dermatology and Venereology, Zaparozhye Medical State University, Zaparozhye, Ukraine.
Background:
Perioral dermatitis (POD) is a common skin disease, and extending the range of treatments available for this condition is important.
Aim:
To evaluate the safety, efficacy and tolerability of praziquantel 3% ointment as monotherapy.
Methods:
This was a single-centre, randomized, single-blind, vehicle-controlled pilot study in adult patients (n = 46) with 4 weeks of treatment and 4 weeks of follow-up. Efficacy was assessed clinically using the Investigator's Global Assessment (IGA) and the Perioral Dermatitis Severity Index (PODSI). Quality of life (QOL) was determined by the Dermatology Quality of Life Index (DLQI).
Results:
PODSI was significantly lower in the praziquantel group than in the placebo (vehicle) group, both during treatment and period. Mean IGA score showed a statistically significant therapeutic advantage of praziquantel over placebo at week 4 (P < 0.001). The praziquantel group experienced a greater improvement in mean DLQI. No serious treatment-related adverse events occurred in either group.
Conclusions:
Praziquantel ointment 3% effectively improves POD symptoms and QOL.
Related Concept Videos
01:15Anthelminthic Agents
01:23Hand hygiene
Hand washing...
01:23Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:23Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...