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Binding of 3H-spiperone to human peripheral lymphocytes: absence of stereospecific high-affinity binding
A Feenstra1, M A Coggiano, R J Wyatt
1Neuropsychiatry Branch, National Institute of Mental Health Neurosciences Center, Washington, DC 20032.
Psychiatry Research
|December 1, 1989
Abstract:
The binding of 3H-spiperone to human peripheral lymphocytes (PBL) was characterized. The (+)-butaclamol displaceable binding of 3H-spiperone was not saturable, and both (+) and (-)-butaclamol were equally potent in displacing 3H-spiperone binding. We did not find evidence for the existence of a high-affinity specific binding site of 3H-spiperone on human PBL.