Related Experiment Video

Updated: Apr 29, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.0K

The relationship between pediatric combination vaccines and market effects

Banafsheh Behzad1, Sheldon H Jacobson, Janet A Jokela

  • 1Banafsheh Behzad is with the Department of Industrial and Enterprise Systems Engineering, University of Illinois at Urbana-Champaign. Sheldon H. Jacobson is with the Department of Computer Science, University of Illinois at Urbana-Champaign. Janet A. Jokela is with College of Medicine, University of Illinois at Urbana-Champaign. Edward C. Sewell is with the Department of Mathematics and Statistics, Southern Illinois University, Edwardsville.

American Journal of Public Health
|May 15, 2014
PubMed

Insights

Market factors influencing pediatric combination vaccine uptake were analyzed. Pentacel

Area of Science:

  • Health Economics
  • Vaccinology
  • Public Health

Background:

  • Pediatric combination vaccines are crucial for public health.
  • Market dynamics significantly influence vaccine uptake and formulary placement.
  • Understanding cost-effectiveness is vital for healthcare providers and policymakers.

Purpose of the Study:

  • To analyze market factors affecting pediatric combination vaccine uptake in the US public sector.
  • To examine the formulary placement of Pediarix and Pentacel between 2009-2012.
  • To identify competitive drivers between Pediarix and Pentacel.

Main Methods:

  • Analysis of market factors influencing pediatric combination vaccine uptake.
  • Examination of formulary placement for Pediarix and Pentacel (2009-2012).
  • Assessment of indirect competition from Merck Haemophilus influenzae type b vaccine and hepatitis B birth dose requirements.

Main Results:

  • Direct competition between Pediarix and Pentacel is influenced by external factors.
  • Merck's Haemophilus influenzae type b vaccine and hepatitis B birth dose impact formulary decisions.
  • Pentacel's inclusion in the lowest cost formulary was contingent on ignoring certain cost factors.

Conclusions:

  • Pentacel's inclusion in the 2009-2012 lowest cost formulary was unlikely without specific cost considerations being overlooked.
  • Healthcare providers' recognition of hepatitis B birth dose administration costs is critical for accurate formulary design.
  • Market competition and scheduling requirements significantly shape pediatric vaccine adoption.

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

16.3K
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

9.8K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
552
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
963
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
409
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
405
Vaccinations01:51

Vaccinations

Overview
44.1K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K