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Nicotinamide enhances skin flap survival
T M Collins1, A Denish, J Sheffield
1Department of Surgery, Temple University Hospital, Philadelphia, Pa. 19140.
Summary
Nicotinamide, an angiogenic factor, may improve random skin flap survival. Studies show increased flap survival rates in rats treated with varying doses of nicotinamide compared to saline controls.
Area of Science:
- Biomedical Engineering
- Vascular Biology
- Dermatology
Background:
- Skin flap survival is crucial in reconstructive surgery.
- Ischemic complications can lead to flap failure.
- Nicotinamide's potential angiogenic properties are under investigation.
Purpose of the Study:
- To evaluate the effect of nicotinamide on abdominal island pedicle skin flap survival in rats.
- To determine the optimal dosage of nicotinamide for enhancing flap viability.
Main Methods:
- An abdominal island pedicle skin flap model was created in male Sprague Dawley rats.
- Rats were divided into five groups receiving saline or varying doses of nicotinamide (25, 50, 100, 200 mg b.i.d.) pre- and post-operatively.
- Flap survival was quantified using Fluorescein injection and necrosis assessment.
Main Results:
- Saline group showed 58.8% survival.
- Nicotinamide groups demonstrated improved survival: 68.6% (25 mg), 82% (50 mg), 80.8% (100 mg), and 86% (200 mg).
- Higher doses of nicotinamide correlated with increased flap survival percentages.
Conclusions:
- Nicotinamide appears to enhance random skin flap survival.
- The angiogenic effects of nicotinamide may contribute to improved flap viability.
- Further research is warranted to explore nicotinamide's clinical application in flap surgery.