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Updated: Apr 29, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
Anjumn Shabir1, Farhan Alhusban1, Yvonne Perrie1
1Aston School of Pharmacy, Aston University, Aston triangle, Birmingham, B4 7ET.
Abstract:
PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.
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