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Acute myocardial infarction complicating active ulcerative colitis: a case report

Eva D Papadimitraki1, Mubarak Ahamed1, Nicholas H Bunce1

  • 1Department of Cardiology, St George's Hospital, Blackshaw Road, London SW17 0QT, UK.

Case Reports in Cardiology
|May 15, 2014
PubMed

Insights

Ulcerative colitis patients may face cardiac risks, including myocardial infarction, especially with specific antibodies and elevated factor VIII. Cardiac MRI aids in diagnosing heart damage in these inflammatory conditions.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Immunology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with potential extraintestinal manifestations.
  • Cardiac involvement in UC, such as pericarditis and myocarditis, is known, but links to ischemic heart disease are less clear.

Observation:

  • A 27-year-old male with anti-PRIII ANCA-positive UC and elevated factor VIII activity presented with acute myocardial infarction.
  • This case highlights an unusual presentation of cardiac complications in a young UC patient.

Findings:

  • The patient experienced an acute myocardial infarction, a condition not definitively linked to UC.
  • Elevated factor VIII activity and ANCA positivity may indicate an increased thrombotic risk in UC.

Implications:

  • This case underscores the importance of considering cardiac events in UC patients, even young ones.
  • Cardiac magnetic resonance (CMR) is a valuable tool for evaluating myocardial damage in patients with inflammatory diseases like UC.
  • Further research is needed to clarify the association between UC, thrombotic risk factors, and ischemic heart disease.

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