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Updated: Aug 18, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
[Morphology and growth characteristics of human renal cell carcinoma in correlation to cytogenetic data]
Abstract:
Previous cytogenetical studies of renal cell carcinomas reported non-uniform results, but some chromosomes or chromosomal segments seemed to be affected more frequently by chromosomal aberration. This study was undertaken to determine a possible association between morphology, growth fraction (Ki-67, APAAP-method), and cytogenetical data of renal cell carcinomas. Our results show a variety of chromosomal aberrations, which do not correlate with morphological typing of the tumors. A single characteristic anomaly could not be found. There is an inverse correlation between complexity of chromosomal aberrations and size of growth fraction. For further interpretation of our results detailed molecular-genetic studies are necessary, which should investigate whether growth factors, oncogenes, or other genes are influenced by the reported chromosomal aberrations.
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