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A survival case in a severe amlodipine intoxication
T El Houari1, I Haddiya2, N El Ouafi1
1Department of Cardiology, Faculty of Medicine, University Mohamed First, Oujda, Morocco.
Case Reports in Cardiology
|May 15, 2014
Summary
Calcium channel blocker overdose can be lethal. This case study highlights hyperinsulinemia euglycemia therapy as a successful treatment for severe amlodipine-induced hypotension, suggesting its use as a first-line therapy.
Area of Science:
- Cardiology
- Toxicology
- Pharmacology
Background:
- Calcium channel blockers (CCBs) are widely prescribed for cardiovascular conditions.
- CCB overdose is a significant cause of mortality.
- Severe hypotension is a common and dangerous outcome of CCB intoxication.
Purpose of the Study:
- To report a case of severe amlodipine intoxication.
- To evaluate the efficacy of hyperinsulinemia euglycemia therapy in managing CCB-induced hypotension.
- To support the use of insulin therapy as a first-line treatment for CCB overdose.
Main Methods:
- Case report of a young woman with amlodipine intoxication.
- Initial treatment with fluids, calcium gluconate, and dobutamine was ineffective.
- Treatment with hyperinsulinemia euglycemia therapy was initiated.
Main Results:
- Hyperinsulinemia euglycemia therapy led to a significant rise in blood pressure within two hours.
- The patient's condition improved, and she was discharged after seven days.
- The positive inotropic effect of insulin was observed.
Conclusions:
- Hyperinsulinemia euglycemia therapy is an effective treatment for severe CCB overdose.
- Insulin therapy demonstrates a positive inotropic effect in managing CCB-induced hypotension.
- This case supports the consideration of insulin therapy as a first-line treatment for CCB overdose.