Effects of C8 alkoxymethylene trimethylammonium chloride on Saccharomyces cerevisiae

The influence of the C8 alkoxymethylene trimethyloammonium chloride on the growth of Saccharomyces cerevisiae and activity of mitochondria was studied. It was shown that the compound at low concentration inhibited growth on glycerol medium, but considerably higher concentration is involved in the inhibition of growth on glucose medium. C8-ATC also exerted another inhibitory effect on genotypically different yeast strains: it appeared that rho- strain is more sensitive than rho+ strain. C8-ATC compound was not capable itself of inducing petite mutations, but is able of retarding the petite inducing activity of the mutagen ethidium bromide. The result pointed out the role of mitochondria in the expression of sensitivity to the investigated compound.