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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:46

Epigenetic Regulation

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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Updated: Apr 29, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Epigenetics in lupus.

Hong Zan1

  • 1Department of Microbiology & Immunology, School of Medicine, University of Texas Health Science Center , San Antonio, TX , USA.

Autoimmunity
|May 16, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetic dysregulation, including DNA methylation and microRNAs, contributes to autoimmune diseases like lupus. Understanding these epigenetic mechanisms is key to developing targeted therapies for lupus pathogenesis.

Keywords:
AutoimmunityautoantibodyepigeneticslupusmicroRNA

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Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Autoimmune diseases stem from genetic factors and environmental exposures.
  • Epigenetic modifications (DNA methylation, histone modifications, microRNAs) alter gene expression without changing DNA sequence.
  • Epigenetic dysregulation is implicated in the development of systemic lupus erythematosus.

Discussion:

  • Investigating the role of epigenetic mechanisms in lupus pathophysiology is crucial.
  • Understanding epigenetic regulation of the immune response in lupus is essential.
  • This issue explores various perspectives on epigenetic mechanisms in lupus.

Key Insights:

  • Epigenetic modifications are critical players in the pathogenesis of autoimmune diseases.
  • Specific epigenetic alterations are linked to systemic lupus erythematosus.
  • Targeted therapies for lupus may arise from a deeper understanding of epigenetic regulation.

Outlook:

  • Further research into epigenetic mechanisms can lead to novel therapeutic strategies.
  • Developing effective, targeted, and well-tolerated treatments for lupus is a primary goal.
  • Continued exploration of epigenetic regulation in lupus promises advancements in patient care.