Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Membrane Fluidity01:26

Membrane Fluidity

13.9K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
13.9K
Membrane Fluidity01:23

Membrane Fluidity

150.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
150.1K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

8.0K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
8.0K
Fluid Mosaic Model01:19

Fluid Mosaic Model

14.6K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
14.6K
Membrane Lipids01:32

Membrane Lipids

19.6K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
19.6K
Membrane Lipids01:32

Membrane Lipids

15.2K
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of water on the microscopic dynamics of 1-butyl-3-methylimidazolium tetrafluoroborate studied by means of quasielastic neutron scattering.

The Journal of chemical physics·2022
Same author

A practical method to account for random phase approximation effects on the dynamic scattering of multi-component polymer systems.

The Journal of chemical physics·2020
Same author

Molecular View on Supramolecular Chain and Association Dynamics.

Physical review letters·2016
Same author

Protein dynamics as seen by (quasi) elastic neutron scattering.

Biochimica et biophysica acta. General subjects·2016
Same author

Dynamics of microemulsions bridged with hydrophobically end-capped star polymers studied by neutron spin-echo.

The Journal of chemical physics·2015
Same author

Linear analysis applied to the comparative study of the I-D-P phase of chlorophyll fluorescence as induced by actinic PS-II light, PS-I light and changes in CO2-concentration.

Photosynthesis research·2014

Related Experiment Video

Updated: Apr 29, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

14.5K

Perfluorooctanoic acid rigidifies a model lipid membrane.

B Brüning1, B Farago2

  • 1Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, Berlin, Germany and Reactor Institute Delft, Delft University of Technology, Delft, The Netherlands.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|May 16, 2014
PubMed
Summary

Perfluorooctanoic acid stiffens lipid bilayers, similar to cholesterol. This study used neutron spin-echo to observe membrane undulations and found a condensing effect from the perfluorinated compound.

More Related Videos

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

8.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K

Related Experiment Videos

Last Updated: Apr 29, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

14.5K
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

8.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K

Area of Science:

  • Biophysics
  • Materials Science
  • Membrane Biophysics

Background:

  • Lipid bilayers are fundamental to cell membranes.
  • Perfluorinated compounds can alter membrane properties.
  • Understanding these interactions is crucial for various applications.

Purpose of the Study:

  • To investigate the effect of perfluorooctanoic acid on lipid bilayer properties.
  • To quantify changes in local lipid bilayer undulations.
  • To compare the effect of perfluorooctanoic acid with cholesterol.

Main Methods:

  • Dynamic light scattering.
  • Neutron spin-echo (NSE) spectroscopy.
  • Studying vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine.

Main Results:

  • Perfluorooctanoic acid was observed to stiffen the lipid bilayer.
  • Neutron spin-echo revealed changes in membrane undulations on time scales up to 200 ns.
  • The effect was comparable to that induced by cholesterol.

Conclusions:

  • Perfluorooctanoic acid acts as a condensing agent on lipid membranes.
  • This condensing effect leads to increased lipid bilayer stiffness.
  • The findings provide insights into the interaction of fluorinated compounds with biological membranes.