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Association between MC4R rs17782313 polymorphism and overeating behaviors.

Z Yilmaz1, C Davis2, N J Loxton3

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The melanocortin 4 receptor (MC4R) gene influences body weight. This study found MC4R rs17782313 is linked to emotional eating and food cravings, potentially explaining its effect on obesity.

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Area of Science:

  • Genetics and Endocrinology
  • Neuroscience and Behavior

Background:

  • Melanocortins regulate appetite and weight.
  • The melanocortin 4 receptor (MC4R) gene is implicated in obesity and weight gain.
  • Mechanisms linking MC4R to weight gain require further elucidation.

Purpose of the Study:

  • To analyze MC4R polymorphisms in relation to body mass index (BMI).
  • To investigate the association between MC4R, eating behaviors, and depressed mood.
  • To explore potential mechanisms of MC4R's influence on body weight.

Main Methods:

  • Genotyping of 328 European ancestry individuals for specific MC4R markers (rs571312, rs17782313, rs489693, rs11872992, rs8087522).
  • Measurement of height and weight to determine BMI.
  • Assessment of depressed mood and overeating behaviors through in-person interviews.

Main Results:

  • A potential association between the MC4R rs17782313 C allele and BMI was observed but did not reach statistical significance after multiple testing correction.
  • The MC4R rs17782313 marker showed significant associations with depressed mood and overeating behaviors.
  • Indirect effects analysis indicated that emotional eating and food cravings, not depressed mood, mediated the relationship between the marker, BMI, and weight.

Conclusions:

  • This study is the first to link MC4R rs17782313 to mood and overeating behaviors.
  • Findings suggest emotional eating and food cravings are key mediators of MC4R's effect on body weight.
  • Results may inform the development of MC4R agonists for treating obesity and disordered eating, pending replication in larger cohorts.