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Updated: Apr 29, 2026
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Published on: July 19, 2021
Bioactive tyrosine-derived cytochalasins from fungus Eutypella sp. D-1
Jing-Tang Liu1, Bo Hu, Yun Gao
1College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, P. R.China, (phone: +86-21-81870970-8004 (X.-L. L.), +86-21-81870972 (X.-Y. L.); fax: +86-21-65334344).
Abstract:
Three new cytochalasins Z24 , Z25 , Z26 (1-3, resp.) and one known compound, scoparasin B (4), were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of the Arctic. The structures of 1-3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF-7 cell line with IC50 of 9.33 μM.
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