Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

159
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
159
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustainable AuNPs@GO Paper-Based SERS Platform with Integrated Chromatography for Point-of-Care Environmental Sensing.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Near-infrared reinforced alginate-tyramine-curcumin gels for alleviation of osteoarthritis in an ACLT murine model.

Journal of materials chemistry. B·2026
Same author

Denosumab and Slow-Jogging Aerobic Exercise in Aromatase Inhibitor-Associated Musculoskeletal Syndrome: A Case Series.

American journal of physical medicine & rehabilitation·2026
Same author

Nanobubbles, not microbubbles, enable ultrasound visualization of the perivascular space: A validation and focused ultrasound modulation study.

Ultrasonics·2026
Same author

Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke.

Journal of neuroengineering and rehabilitation·2026
Same author

Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson's disease mouse model.

Frontiers in aging neuroscience·2026
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Apr 29, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.2K

Tertiary-amine functionalized polyplexes enhanced cellular uptake and prolonged gene expression.

Chia-Wen Lo1, Yung Chang2, Jyun-Lin Lee1

  • 1Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.

Plos One
|May 16, 2014
PubMed
Summary
This summary is machine-generated.

Poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) enhances ultrasound-mediated gene transfection. Optimized PDMAEMA/DNA ratios improve in vivo gene expression duration, showing promise for therapeutic applications.

More Related Videos

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.6K
Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation
07:40

Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation

Published on: July 31, 2015

8.0K

Related Experiment Videos

Last Updated: Apr 29, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.2K
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.6K
Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation
07:40

Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation

Published on: July 31, 2015

8.0K

Area of Science:

  • Biotechnology
  • Gene Therapy
  • Ultrasound Applications

Background:

  • Ultrasound (US) facilitates DNA transport across cell membranes.
  • Current US-mediated gene transfection exhibits low efficiency and short expression duration.

Purpose of the Study:

  • To evaluate Poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) as a carrier for US-mediated gene transfection.
  • To assess the in vitro and in vivo effects of PDMAEMA on transfection efficiency and expression duration.

Main Methods:

  • pCI-neo-luc DNA and PDMAEMA were transfected into cultured cells and mouse muscle using 1-MHz pulse US.
  • In vitro and in vivo transfection efficiencies and gene expression durations were analyzed.
  • The impact of PDMAEMA to DNA weight ratios was investigated.

Main Results:

  • Strong luciferase expression was observed in vitro at 10 days, irrespective of US exposure.
  • Effective transfection in vivo was achieved only in US-exposed groups.
  • Transfection efficiency depended on the PDMAEMA/DNA weight ratio, with lower ratios (e.g., 0.25) showing prolonged in vivo expression (≥45 days).

Conclusions:

  • PDMAEMA serves as an effective carrier for US-mediated gene delivery.
  • Optimizing the PDMAEMA/DNA ratio is crucial for enhancing in vivo transfection efficiency and duration.
  • This approach holds potential for improving gene therapy outcomes.