[Observations on substance P in the brain and spinal cord in schizophrenia]

The regional distribution of substance P in postmortem brain and spinal cord of 5 cases of schizophrenia were investigated using the immunohistochemical PAP and ABC technique. Substance P immunoreactive fibers were primarily found in Substantia nigra, nucleus tractus spinalis n. trigemini, nucleus tractus solitarii, nucleus spinalis n. vestibuli, nucleus ambiguous, Central gray matter of the midbrain, globus pallidus and cornua posteriora spinales. The 5 cases showed no differences to the controls. These results agree with the finding reported abroad that the brain tissues were measured by radioimmunoassays. It was also discussed on study method of substance P in Central nervous system.