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Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

469
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
469

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Gestation-specific D-dimer reference ranges: a cross-sectional study.

N Murphy1, D I Broadhurst, A S Khashan

  • 1INFANT centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Ireland; Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Ireland.

BJOG : an International Journal of Obstetrics and Gynaecology
|May 16, 2014
PubMed
Summary
This summary is machine-generated.

D-dimer levels steadily increase throughout pregnancy, with 95th percentile values exceeding non-pregnant cut-offs. This establishes new reference ranges for diagnosing venous thromboembolism (VTE) in pregnant individuals.

Keywords:
D-dimerpregnancyreference rangevenous thromboembolism

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Clinical Chemistry

Background:

  • D-dimer is a marker of coagulation activation.
  • Establishing accurate reference ranges for D-dimer during pregnancy is crucial for diagnosing venous thromboembolism (VTE).
  • Existing non-pregnant D-dimer cut-offs may not be suitable for pregnant populations.

Purpose of the Study:

  • To establish gestation-specific reference ranges for D-dimer in healthy singleton pregnancies.
  • To determine the 5th and 95th percentiles of D-dimer concentrations across gestational weeks.
  • To compare postpartum D-dimer levels with those during gestation.

Main Methods:

  • Cross-sectional study involving 760 healthy pregnant women.
  • Simultaneous-quantile regression used to model D-dimer concentrations against gestational age (weeks 6-42).
  • Mann-Whitney U-tests compared D-dimer distributions during pregnancy and postpartum.

Main Results:

  • A continuous, steady increase in median D-dimer concentrations was observed throughout gestation.
  • The 95th percentile D-dimer estimates exceeded the non-pregnant cut-off (224 ng/ml) at all gestational time-points.
  • D-dimer concentrations began returning to normal levels in the immediate postpartum period.

Conclusions:

  • D-dimer concentrations increase progressively during normal pregnancy.
  • The study provides new, gestation-specific 95th percentile cut-offs for D-dimer, aiding VTE diagnosis in pregnancy.
  • Further research comparing D-dimer in women with and without deep vein thrombosis (DVT) is warranted.