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Approaching the in vitro clinical trial: engineering organs on chips
A K Capulli1, K Tian, N Mehandru
1Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA 02138, USA. kkparker@seas.harvard.edu.
Lab on a Chip
|May 16, 2014
Summary
Organs on Chips (OOCs) offer a promising new approach to drug development, enhancing preclinical testing by modeling patient physiology. This technology aims to improve therapeutic evaluations and reduce costly failures in the pharmaceutical industry.
Area of Science:
- Biotechnology and Pharmaceutical Sciences
- Translational Medicine
- In Vitro Modeling
Background:
- Current in vitro cell culture and animal models in pharmaceutical research have limitations, leading to significant costs and potential patient harm.
- There is a critical need for more clinically and physiologically relevant preclinical models to improve drug development success rates.
Purpose of the Study:
- To introduce Organs on Chips (OOCs) as an advanced tool for enhancing preclinical drug development.
- To highlight the necessity of integrating clinical observations and methods into the design, build, and testing of OOCs.
- To position OOCs as patient-specific models for more effective medicinal therapeutic evaluation.
Main Methods:
- Development of Organs on Chips (OOCs) technology.
- Incorporation of clinical observations and methods into OOC design and application.
- Utilizing OOCs to model human health and disease states for preclinical testing.
Main Results:
- Organs on Chips (OOCs) provide a more physiologically relevant platform compared to traditional models.
- The patient-specific modeling approach with OOCs has the potential to improve the accuracy of therapeutic evaluations.
- This technology can reduce the incidence of costly and potentially fatal failures in drug development.
Conclusions:
- Organs on Chips (OOCs) represent a significant advancement in preclinical drug development.
- Founding OOC technology on clinical insights is crucial for its successful translation and application.
- OOCs offer a promising pathway to better evaluate medicinal therapeutics by modeling the patient more effectively.
