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Updated: Apr 29, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Does tautomerization of FapyG influence its mutagenicity?
Nihar R Jena1, Alan E Mark, Phool C Mishra
1Discipline of Natural Sciences, Indian Institute of Information Technology, Design and Manufacturing, Khamaria, Jabalpur-482005 (India); School of Chemistry and Molecular Biosciences, University of Queensland, QLD-4072 (Australia). nrjena@iiitdmj.ac.in.
Abstract:
Oxidative degradation of guanine to 2,6-diamino-4-oxo-5-formamidopyrimidine (FapyG) is believed to be mutagenic. It has been proposed recently that the enol tautomer of FapyG is mainly responsible for this effect leading to a guanine-to-thymine mutation (T. H. Gehrke, U. Lischke, K. L. Gasteiger, S. Schneider, S. Arnold, H. C. Muller, D. S. Stephenson, H. Zipse, T. Carell, Nat. Chem. Biol.- 2013, 9, 455-461). Here, density functional methods suggest that the enol tautomer of FapyG might not be responsible for the proposed guanine-to-thymine mutation. Instead, it might result in a guanine-to-adenine mutation.
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