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Published on: April 30, 2020
Extremes of age are associated with indeterminate QuantiFERON-TB gold assay results
Marc Tebruegge1, Hans de Graaf2, Priya Sukhtankar2
1Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom Department of Paediatric Infectious Diseases & Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom Department of Paediatrics, Faculty of Medicine, The University of Melbourne, Parkville, Australia m.tebruegge@soton.ac.uk.
Abstract:
Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.
