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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Statin use is associated with improved overall survival without affecting patency and limb salvage rates following

Hasan H Dosluoglu1, Sina Davari-Farid2, Leili Pourafkari2

  • 1Department of Anesthesiology, SUNY-Buffalo, Buffalo, NY, USA Department of Surgery, SUNY-Buffalo, Buffalo, NY, USA.

Vascular Medicine (London, England)
|May 16, 2014
PubMed

Insights

Statin drug use in chronic limb ischemia patients undergoing revascularization was linked to better survival rates. However, statins did not significantly impact vessel patency or limb salvage outcomes.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Pharmacology

Background:

  • Chronic limb ischemia (CLI) poses significant risks for patients requiring revascularization.
  • The role of statin therapy in optimizing outcomes after revascularization for CLI remains an area of investigation.

Purpose of the Study:

  • To evaluate the association between statin use and outcomes including patency, limb salvage, and survival in patients with CLI undergoing revascularization.
  • To identify factors independently associated with survival in this patient cohort.

Main Methods:

  • Retrospective review of 717 patients who underwent revascularization for intermittent claudication or CLI between May 2001 and December 2009.
  • Patients were stratified into statin and non-statin groups based on therapy at the time of revascularization.
  • Comparison of early postoperative outcomes, graft patency, limb salvage rates, and survival between the groups.

Main Results:

  • Of 717 patients, 397 (55.4%) were on statins. Major adverse cardiac events (MACE) were significantly lower in the statin group.
  • Graft patency and limb salvage rates were comparable between statin and non-statin users.
  • Survival rates were significantly higher in patients receiving statin therapy.

Conclusions:

  • Statin therapy is associated with improved survival in patients undergoing revascularization for chronic limb ischemia.
  • Statin use did not demonstrate a significant association with improved long-term graft patency or limb salvage rates.
  • Non-statin use, coronary artery disease, COPD, renal insufficiency, critical limb ischemia, and age >70 were independent predictors of decreased survival.

Keywords:
arterial occlusive diseasesleglipidsmenstatins

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