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Updated: Apr 29, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
Published on: January 26, 2024
PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes
Alper Baspinar1, Engin Cukuroglu1, Ruth Nussinov2
1Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, 34450 Istanbul, Turkey.
Abstract:
The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.
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