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Thyroid dysfunction and choleduocholithiasis.
Hossein Ajdarkosh1, Mohammad Reza Khansari1, Masoud Reza Sohrabi1
1Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Middle East Journal of Digestive Diseases
|May 16, 2014
Summary
Thyroid dysfunction, particularly hypothyroidism, is linked to bile duct stones. Testing thyroid function is recommended for patients with gallstones and bile duct stones, as it may be a predisposing factor.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Disorders
Background:
- Hypothyroidism disrupts lipid metabolism, contributing to gallstone formation.
- This study investigates thyroid function patterns in patients diagnosed with common bile duct (CBD) stones.
Purpose of the Study:
- To evaluate thyroid function in patients with common bile duct stones.
- To determine if thyroid disorders are associated with CBD stone presence.
Main Methods:
- A case-control study included 151 patients with CBD stones (cases) and healthy controls.
- Fasting blood samples were analyzed for thyroid hormones (T4, TSH) and lipid profiles (TG, cholesterol, HDL, LDL).
- Demographic and anthropometric data were collected via questionnaire.
Main Results:
- Mean TSH levels were slightly higher in patients with CBD stones compared to controls.
- Subclinical hypothyroidism (TSH > 5 MU/L) was observed in 30.6% of cases versus 22.5% of controls.
- Significant differences in triglycerides, HDL, and LDL levels were noted between cases and controls.
Conclusions:
- An association exists between thyroid disorders and the presence of bile duct stones.
- Hypothyroidism may predispose individuals to developing gallstones and CBD stones.
- Routine thyroid function testing is advised for patients with gallstones and CBD stones.
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