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Upper Gastrointestinal Bleeding in Khorramabad City in 2011A Single Referral Center Experience
Koroush Ghanadi1, Khatereh Anbari2, Zia Obeidavi3
1Assistant Professor, Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Insights
Acute upper gastrointestinal bleeding (UGIB) is frequently caused by peptic ulcers. Regular Non-Steroidal Anti-Inflammatory Drug (NSAID) use is a significant risk factor for UGIB, highlighting the need for preventive strategies.
Area of Science:
- Gastroenterology
- Internal Medicine
- Epidemiology
Background:
- Acute upper gastrointestinal bleeding (UGIB) is a prevalent medical emergency contributing significantly to mortality and morbidity.
- This study investigated the causes and risk factors of UGIB within a referral center setting.
Purpose of the Study:
- To identify the primary causes of acute upper gastrointestinal bleeding (UGIB).
- To determine the risk factors associated with UGIB in a specific patient population.
Main Methods:
- A cross-sectional study was conducted over one year, including patients with acute UGIB and a matched control group.
- Data were collected via a self-made questionnaire, encompassing demographic information, clinical manifestations, and endoscopic findings.
- Statistical analysis involved chi-square tests, Fisher's exact test, and Odds Ratio estimation.
Main Results:
- Peptic ulcer disease (42.7%) was the most frequent cause of acute UGIB, followed by erosive gastritis and esophageal varices (19.8% each).
- A history of regular Non-Steroidal Anti-Inflammatory Drug (NSAID) consumption was significantly associated with UGIB (Odds Ratio 3.8).
- 35.5% of UGIB episodes occurred in patients over 60 years of age.
Conclusions:
- Peptic ulcer disease is the leading cause of acute UGIB in the studied region.
- Regular NSAID use is correlated with UGIB episodes, while alcohol consumption, smoking, and gender were not significant risk factors.
- Identifying at-risk individuals and implementing preventive measures are crucial for reducing UGIB incidence and complications.
Background:
Acute upper gastrointestinal bleeding (UGIB) is a common medical emergencyand is known as one of the main causes of mortality and morbidity. Thisresearch was conducted to study the causes and risk factors for UGIB, in areferral center.
Methods:
In this cross sectional study, carried out in a one year period, all patientswith acute UGIB living in Khorramabad city and surrounding area, entered thestudy. A control group with age and sex matched was selected from outpatientvisits and their relatives who had referred to hospital clinics. Data collectingtool was a self-made questionnaire, demographic, clinical manifestations andendoscopic findings. The data was analyzed using chi-square test, Fisher exacttest and Odds ratio estimation.
Results:
Sixty-two patients with acute UGIB were studied, 67.7% of them weremales. The mean age of patients was 54.5±12.1. The most common causesof acute UGIB were peptic (42.7%), erosive gastritis (19.8%) and esophagealvarices (19.8%). 29%, and 9.7% of patients, and control group had a history ofregular consumption of Non Steroidal Anti-Inflammatory Drugs ( Odd' s ratio3.8, CI: 1.3-4.8). 35.5% of episodes of acute UGIB were in age more than 60years.
Conclusion:
Peptic ulcer disease is the most common cause of acute UGIB in our region.Episodes of acute UGIB were correlated with regular NSAIDs use, but notwith alcohol consumption, smoking, and gender. Identifying people who are atrisk and providing preventive strategies can reduce the rate of this disease andits complications.
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