Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

20
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
20
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

30
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
30
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

44
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
44

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review of the efficacy of rituximab in the management of central nervous system involvement among adults with Sjögren's disease.

BMC rheumatology·2026
Same author

Aptamer-tagged exosome-coated Bismuth ferrite-mesoporous silica nanoparticle for chemoradiotherapy and CT/MR imaging of non-small cell lung cancer.

International journal of biological macromolecules·2026
Same author

Systemic Low Dose Corticosteroid Improves Early Postoperative Knee Function and Pain Intensity in Patients Undergoing Unilateral Total Knee Arthroplasty: A Blinded Controlled Randomized Clinical Trial.

JB & JS open access·2026
Same author

Treatment Outcomes of Lobular Granulomatous Mastitis: Impact of Hyperprolactinemia, Diabetes, and Erythema Nodosum-Insights From a 7-Year Cohort Study.

The breast journal·2026
Same author

Rituximab and Intravenous Immunoglobulin (IVIG) for Refractory Eosinophilic Fasciitis: A Case Report.

Clinical case reports·2026
Same author

Effect of berberine-loaded mesoporous silica nanoparticles and their combination with collagen/hydroxyapatite sponge scaffold on the regeneration of rabbit skull defects.

International journal of biological macromolecules·2025

Related Experiment Video

Updated: Apr 29, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

1.1K

Autoimmune pancreatitis: a case report.

Masoumeh Salari1, Mousareza Hosseini2, Sirous Nekooei3

  • 1Assistant Professor, Department of Internal Medicine, Ghaem Hospital, Mashhad University of Medicine Sciences, Mashhad, Iran.

Middle East Journal of Digestive Diseases
|May 16, 2014
PubMed
Summary

Autoimmune pancreatitis, a chronic inflammatory condition, presents with jaundice and abdominal pain. Diagnosis involves imaging, IgG4 levels, and response to steroids.

Keywords:
Autoimmune pancreatitisImmunoglobulin G4Sclerosant colangitis

More Related Videos

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

643

Related Experiment Videos

Last Updated: Apr 29, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

1.1K
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

643

Area of Science:

  • Gastroenterology
  • Immunology

Background:

  • Autoimmune pancreatitis (AIP) is a fibro-inflammatory condition.
  • Diagnosis relies on imaging, IgG4 levels, autoantibodies, histopathology, and steroid response.

Observation:

  • A 41-year-old female presented with jaundice and abdominal pain.
  • Elevated alkaline phosphatase (ALP) and erythrocyte sedimentation rate (ESR) were noted.

Findings:

  • Magnetic resonance cholangiopancreatography (MRCP) revealed pancreatic and bile duct strictures and dilations.
  • Elevated immunoglobulin G4 (IgG4) levels and antinuclear antibodies were detected.

Implications:

  • This case highlights the diagnostic challenges of autoimmune pancreatitis.
  • Illustrates the importance of considering IgG4-related disease in patients with biliary and pancreatic duct abnormalities.