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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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MicroRNAs in pathogenesis of breast cancer: Implications in diagnosis and treatment

Nirav R Shah1, Hexin Chen1

  • 1Nirav R Shah, Hexin Chen, Department of Biological Science, Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, United States.

World Journal of Clinical Oncology
|May 16, 2014
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer, acting as either oncogenes or tumor suppressors. Understanding their roles offers new therapeutic and diagnostic strategies for this disease.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Dysregulation of miRNAs is implicated in tumorigenesis, particularly in breast cancer.
  • miRNAs can act as oncogenes (oncomiRs) or tumor suppressors in cancer development.

Purpose of the Study:

  • To review dysregulated miRNAs in breast cancer.
  • To discuss the therapeutic potential of miRNAs in breast cancer.
  • To highlight the role of miRNAs in breast cancer diagnosis and prognosis.

Main Methods:

  • Literature review of scientific articles on miRNAs in breast cancer.
  • Analysis of miRNA expression patterns in breast cancer.
  • Discussion of miRNA-based therapeutic strategies and diagnostic approaches.

Main Results:

  • Specific miRNAs are aberrantly expressed in breast cancer, influencing tumor suppressor genes or oncogenes.
  • Oncogenic miRNAs are upregulated, promoting tumorigenesis.
  • Tumor suppressor miRNAs are downregulated, contributing to cancer progression.

Conclusions:

  • miRNA dysregulation is a significant factor in breast cancer pathogenesis.
  • Targeting specific miRNAs holds promise for novel anti-cancer therapies.
  • miRNA detection in blood plasma may aid in early breast cancer diagnosis and prognosis.
Keywords:
Breast cancerCancer stem cellsDiagnostic markersDrug resistanceMicroRNAs

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